Cholibrium is a daily mushroom supplement from Simple Promise™ that brings 10 time-honored mushrooms, including reishi, lion’s mane, cordyceps, shiitake and maitake, together in just two capsules. It is made to support a healthy heart, healthy cholesterol levels already in the normal range, steady energy and overall vitality as you age.*
Editorial score from Wellness Press Now based on the ingredients, the label, cost per day and refund terms. It is not a customer rating. How we score
Yes. Cholibrium is one of the most complete mushroom formulas for heart and daily wellness support, with 10 mushrooms in one simple 2-capsule routine and a full 365-day money-back guarantee. Four of its key mushrooms, cordyceps, reishi, shiitake and lion’s mane, come at a clearly listed 266 mg each, backed by six more in a supporting blend. It is a great fit for adults over 50 who want natural, everyday support for a healthy heart, healthy cholesterol levels already in the normal range, steady energy and a strong immune system.* Customers on the official store rate it 4.17 out of 5.
Cholibrium is a daily mushroom supplement from Simple Promise™, an American supplement company based in Camas, Washington. It is made for adults, especially men and women over 50, who want natural support for heart health, healthy cholesterol and blood pressure levels already in the normal range, healthy weight, energy and overall vitality.* Each bottle holds 60 vegetable capsules, so one bottle is a full 30-day supply at two capsules a day.
Mushrooms have been part of traditional wellness in Asia for thousands of years, and today they are among the most popular natural supplements in America. Instead of choosing just one, Cholibrium brings 10 well-known mushrooms together in one formula, so you get the different strengths of each: reishi for calm and immune balance, lion’s mane for focus, cordyceps for energy and endurance, shiitake and maitake for heart support, and turkey tail and chaga for antioxidant protection.*
| Product type | Dietary supplement, vegetable capsules |
| Made by | Simple Promise™, Camas, WA · 1-800-259-9522 |
| Formula | 10 mushrooms, 1,330 mg per serving |
| Serving | 2 capsules daily, 20–30 minutes before a meal |
| Bottle size | 60 capsules (30-day supply) |
| Price | $59 (1 bottle), $147 (3 bottles), $234 (6 bottles) |
| Shipping | Free on all U.S. orders |
| Guarantee | 365-day money-back guarantee |
| Customer rating | 4.17/5 on the official store (110 reviews) |
| Where to buy | Official website (best for package pricing and the full guarantee), also listed on Amazon |
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Here is the Cholibrium label, retyped so it is easy to read. Four mushrooms are listed with their exact amount, and six more share a 266 mg blend, for a total of 1,330 mg of mushrooms in every serving.
| Amount Per Serving | %DV |
|---|---|
| Cordyceps Powder (Cordyceps sinensis, mycelium) | 266 mg ** |
| Reishi Mushroom Extract (Ganoderma lucidum, fruiting bodies) | 266 mg ** |
| Shiitake Mushroom Extract (Lentinus edodes, fruiting bodies) | 266 mg ** |
| Lion’s Mane (Hericium erinaceus, fruiting bodies) | 266 mg ** |
| Proprietary Blend | 266 mg ** |
| Maitake Mushroom Extract (Grifola frondosa), Turkey Tail (Coriolus versicolor), Chaga Mushroom Extract (Inonotus obliquus), Royal Sun Agaricus Extract (Agaricus blazei), White Button Mushroom Extract (Agaricus bisporus), Wood Ear Fungus Extract (Auricularia auricula), all fruiting bodies | |
Each mushroom in Cholibrium brings something different. Here is what each one is known for, in plain English.
Cordyceps is famous in traditional Chinese wellness as an energy and stamina mushroom. Research suggests it may support the way the body uses oxygen during activity, which is why it is popular with active older adults.*
Traditional use: energy & staminaKnown as the “mushroom of immortality” in Asia, reishi has been treasured for over 2,000 years. It is valued for supporting a balanced immune system, a sense of calm, and healthy cholesterol levels already in the normal range.*
Traditional use: immunity & calmThe familiar kitchen mushroom is also one of the most studied. Shiitake contains eritadenine and beta-glucans, compounds researched for their role in supporting healthy cholesterol levels.*
Studied for: healthy cholesterolLion’s mane has a shaggy, white look and a big following for supporting focus, memory and mental clarity. Early research also looks at its role in healthy fat metabolism.*
Popular for: focus & memoryThe “dancing mushroom” of Japan is rich in beta-glucans and has been studied for supporting healthy cholesterol and energy metabolism.*
Rich in beta-glucansNamed for its colorful bands, turkey tail is packed with antioxidant compounds and is one of the best-known mushrooms for immune support.*
Known for: immune supportChaga grows on birch trees in cold northern forests and has been used for centuries in Siberia and Eastern Europe. It is one of the richest natural sources of antioxidants.*
Known for: antioxidantsOriginally from Brazil, this almond-scented mushroom is valued for its antioxidants and for supporting healthy immune function.*
Traditional use: immunityThe most popular mushroom in the world, white button brings beta-glucans and everyday nutrients to the formula.*
Rich in beta-glucansA staple of Asian cooking for centuries, wood ear contains polysaccharides studied for supporting healthy circulation and cholesterol levels already in the normal range.*
Traditional use: circulation*These statements have not been evaluated by the Food and Drug Administration. Research on many mushrooms is still growing, and individual results vary.
Cholibrium works on a simple idea: instead of relying on a single ingredient, it combines 10 mushrooms that support your body in complementary ways. Simple Promise describes it as a natural 3-step process:
Mushrooms like reishi and cordyceps are known as adaptogens, natural ingredients that help the body stay balanced, calm and energized day to day.*
Turkey tail, chaga, shiitake and maitake are rich in beta-glucans and antioxidants that help support a healthy immune response and protect cells from everyday stress.*
Shiitake, maitake, reishi and wood ear have been studied for supporting healthy cholesterol and circulation, part of whole-body cardiovascular wellness.*
Product images from Simple Promise and its Amazon listing. *These statements have not been evaluated by the FDA.
For adults who want a simple, natural way to support heart health, energy and immunity, Cholibrium is a well-rounded choice. Its mushrooms have centuries of traditional use, and several, including reishi, shiitake, maitake and cordyceps, have been studied for heart, energy and immune support. Customers agree: Cholibrium holds a 4.17 out of 5 rating on the official Simple Promise store.
Mushroom supplements work gradually, and Simple Promise recommends at least 60 to 90 days of daily use. Here is the pattern many people describe:
Two capsules before a meal becomes part of your routine. No dramatic change is expected yet, and that is completely normal.
Some people say their energy starts to feel steadier and more consistent through the day.
Many describe a general sense of steadier, everyday wellness. Your regular check-ups are a great way to see how you are doing.
Individual results vary. These are general patterns people report, not guaranteed outcomes.
Take two capsules at the same time every day, 20 to 30 minutes before a meal with a full glass of water. Pair it with heart-friendly habits you already enjoy, like a daily walk and plenty of vegetables, and give it at least 90 days. That is why the 3-bottle package is the most popular choice.
The mushrooms in Cholibrium have a long history of food and traditional use, and mushroom supplements are generally well tolerated. A few people notice mild stomach upset at first, which taking the capsules before a meal with a full glass of water usually helps.
Cholibrium is a supplement that supports your daily routine, so keep taking any medicine your doctor prescribed.
Here are the current prices on the official Simple Promise store. Every package ships free in the U.S., is a one-time payment with no auto-billing, and is covered by the same 365-day money-back guarantee. The more bottles you choose, the more you save compared with the regular price of $99 a bottle.
| Package | Total | Per bottle | Per day | You save vs. $99 |
|---|---|---|---|---|
| 1 bottle | $59 | $59 | ~$1.97 | $40 |
| 3 bottles | $147 | $49 | ~$1.63 | $150 |
| 6 bottles | $234 | $39 | ~$1.30 | $360 |
Most people choose the 3-bottle package. It covers the 60 to 90 days of daily use the maker recommends and brings the price down to $49 a bottle. If you already know you want Cholibrium as part of your routine, the 6-bottle package gives you the lowest price, about $1.30 a day. Because the 365-day guarantee covers every package, buying more never shortens your protection. Prices can change, so the official order page always shows today’s price.
Simple Promise backs every Cholibrium order with a 365-day money-back guarantee, one of the longest in the supplement world. If it is not right for you, contact customer support at 1-800-259-9522 within a year of your purchase for a refund. Keep your order confirmation handy to make it quick and easy.
The official Simple Promise store publishes customer reviews for Cholibrium. On October 20, 2026 it showed:
“All I can say is that is a fantastic product!”
Store review (name not shown), March 28, 2026
“This product appears to be working, and will give it more time to fully do what it suppose to do.”
Jimmy A., August 24, 2026
“All good so far.”
Store review (name not shown), August 30, 2026
Reviews are quoted briefly from the official Simple Promise store, with names shortened. We did not collect or edit these reviews, and individual results vary. The rating above is the store’s own figure, not a Wellness Press Now score.
Simple Promise sells Cholibrium on its official website and also lists it on Amazon, where it appears as a “9-in-1 Mushroom Complex” because black fungus and white button are counted as one blend. It is the same 10-mushroom formula.
For most buyers, the official website is the better choice. It offers the 3- and 6-bottle package discounts, free U.S. shipping, a one-time payment and the full 365-day money-back guarantee directly from the maker. Cholibrium is not sold in Walmart, Walgreens or other physical stores, so be careful with third-party sellers.
Cholibrium is a daily mushroom supplement from Simple Promise that combines 10 mushrooms, including reishi, lion's mane, cordyceps, shiitake, maitake, turkey tail and chaga, in two vegetable capsules. It is designed to support heart health, healthy cholesterol and blood pressure levels already in the normal range, energy and overall wellness.*
Each 2-capsule serving contains cordyceps powder (266 mg), reishi extract (266 mg), shiitake extract (266 mg) and lion's mane (266 mg), plus a 266 mg proprietary blend of maitake, turkey tail, chaga, royal sun agaricus, white button mushroom and wood ear (black fungus). That is 1,330 mg of mushrooms per serving. Other ingredients are a vegetable capsule, microcrystalline cellulose and magnesium stearate.
Adults take two capsules once a day, ideally 20 to 30 minutes before a meal with an 8 oz glass of water. One bottle holds 60 capsules, a 30-day supply. The maker suggests using it daily for at least 60 to 90 days.
Cholibrium brings together mushrooms that have been used for centuries and studied for heart, energy and immune support, so it is a well-rounded choice for daily wellness. Many customers say they feel good on it, and it holds a 4.17 out of 5 rating on the official store. Results vary from person to person and build with consistent daily use.
Most people give it 60 to 90 days of daily use, which is what the maker recommends. Some say energy feels steadier within a few weeks. If you are tracking cholesterol or blood pressure, your regular check-ups with your doctor are the best way to see how you are doing.
Mushroom supplements are generally well tolerated. A few people notice mild stomach upset at first, which taking the capsules before a meal with water usually helps. Anyone with a mushroom allergy should avoid it.
Reishi, cordyceps and chaga may add to the effects of blood thinners, blood pressure medicine and diabetes medicine. If you take any of these, a quick check with your pharmacist or doctor before you start is a smart idea.
No. Cholibrium is a dietary supplement that supports your daily routine. Keep taking any medicine your doctor prescribed, and talk with your doctor before making changes.
On the official Simple Promise store, one bottle is $59, three bottles are $147 ($49 each) and six bottles are $234 ($39 each), compared with a regular price of $99 a bottle. Shipping is free in the U.S. Prices can change, so the order page shows today's price.
No. Each order is a one-time payment with no automatic billing.
Yes. Simple Promise backs every purchase with a 365-day money-back guarantee, so you have a full year to decide whether it is right for you.
Yes, Simple Promise also lists Cholibrium on Amazon. For the package discounts and the full 365-day guarantee, the official website is usually the best place to order.
The Amazon listing counts black fungus and white button mushroom as one combined blend, so it shows 9 items. The Supplement Facts label lists all 10 mushrooms by name, and it is the same formula.
The capsule is plant-based (hypromellose), and the formula contains only mushroom ingredients plus common capsule fillers. Amazon describes it as vegan. Check the bottle for the latest allergen details if you follow a strict diet.
Cholibrium is made by Simple Promise, a U.S. supplement company based in Camas, Washington. It is made in a GMP-certified facility, according to the company. Customer support is available at 1-800-259-9522.
Cholibrium is designed with adults over 50 in mind, and its mushrooms have a long history of food and traditional use. As with any supplement, older adults who take daily prescription medicine should check with their pharmacist first.
Nothing at all. It comes in unflavored capsules, so there is no earthy mushroom taste.
Many people combine heart-support supplements, but the best mix depends on your health and medicines. Ask your pharmacist to look over your full list before you combine products.
Store the bottle at room temperature, away from heat and moisture, and keep it out of reach of children. Do not use it if the safety seal is damaged or missing.
Because the maker recommends 60 to 90 days of daily use, the 3-bottle package is the most popular choice. The 6-bottle package gives the lowest price, $39 a bottle, and every package is covered by the same 365-day guarantee.
Cholibrium is a thoughtfully made, wide-ranging mushroom formula that makes natural heart and wellness support simple. Ten time-honored mushrooms, including reishi, lion’s mane, cordyceps, shiitake and maitake, come together in just two capsules a day, with the four headline mushrooms clearly dosed and a 4.17-star rating from customers on the official store.
If you are over 50 and want an easy, natural way to support a healthy heart, healthy cholesterol levels already in the normal range, steady energy and a strong immune system, Cholibrium is a great choice to try. Start with the popular 3-bottle package to give it the 60 to 90 days it needs, and let the 365-day money-back guarantee take the risk off the table. If you take a blood thinner or diabetes medicine, a quick word with your pharmacist is a good idea.
Founder & Editor · Wellness Press Now
Chris started Wellness Press Now with one simple goal: to help readers over 50 feel confident about the supplements they choose. Every review begins with the official Supplement Facts label and today’s order-page prices, then looks at each ingredient through trusted research from the NIH Office of Dietary Supplements, NCCIH and MedlinePlus, all explained in plain, friendly English.
💚 These reviews are here to help you learn and compare. Your own doctor knows your health best, so they make a wonderful partner as you decide what is right for you.
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